– updated June 2021
We are looking for a highly motivated and dynamic individual to join our team. The successful candidate would have a key role in most of the lab’s projects, provide support and fulfill organizational needs. He/She will manage the laboratory, control the budget and help supervise ongoing projects. Besides providing technical and scientific support to students and postdocs, the candidate will directly be in charge of specific projects. He/She will help to plan new projects, write grant applications, reports and scientific papers. The propensity to read and autonomously design studies and experiments is encouraged. At any moment, the candidate will be able to interact with Dr Paganelli and senior members of the research team to ensure proper experimental design, analysis, and address technical concerns. The candidate will work in a young, energetic and international environment where everyone is committed to this ambitious translational project, and will de able to take advantage of the outstanding new Research Center of CHU Sainte-Justine, the close proximity with the patients, the clinical team of the pediatric hepatology unit and the liver transplantation programs. Involvement in scientific publications will be assured, in accordance with the contributions provided.
Specifically, the candidate will be responsible for:
- Stem cell culture (human and mammalian stem cells, primary hepatocytes, co-cultures, organoids)
- In vitro cell differentiation and assessment of the quality of differentiation (flow cytometry, immunostaining, confocal microscopy, RT-qPCR, immunoblotting, enzymatic functions, drug metabolism)
- Molecular biology (cloning, transfection/transduction, qPCR, genome editing)
- Management of animal colonies and in vivo experiments
- Lab management (orders, supplies)
Requirements and skills
- Strong motivation: the candidate should share the lab’s vision and aims
- Master’s degree in cellular/molecular biology or related fields and experience (as a graduate student or research assistant) in a research laboratory working on human stem cells and/or hepatology.
- Solid technical skills. The candidate must master the following technical skills: cell culture, immunostaining, immunoblotting, flow cytometry, ELISA, cloning, transfection, RT-qPCR.
- Experience with embryonic stem cells or iPSCs, in vitro differentiation protocols and GLP/GMP standards would be a plus.
- Good communication skills and the ability to interact with the staff and with external contacts in English. At least basic knowledge of the French language is required.
- Must possess a high level of initiative and the ability to work with little to no supervision.
Terms of employment
Full-time job with an indeterminate term contract (subject to funds availability), with a probationary period. The salary and other conditions of employment will be based on institutional scales for responsibilities and experience.
Start date: as soon as possible
Application: send your CV and references to Dr. Paganelli at firstname.lastname@example.org
MSc, PhD and Postdoc positions
We are looking for graduate students motivated to carry out cutting-edge research in his regenerative medicine-centered laboratory. Main focus of the lab is the study and treatment of liver disease using liver organoids generated from human induced pluripotent stem cells (iPSC). Such organoids are used in the lab to understand the physiology of liver development and regeneration, as well as the pathophysiology of complex liver diseases such as fibrosis and cirrhosis or rare genetic liver conditions. The liver organoids are also at the heart of the Encapsulated Liver Tissue, a technology capable of replacing liver functions and treating acute liver failure. Such a technology was conceived in Dr. Paganelli’s laboratory and is now being developed into a cell therapy product by Morphocell Technologies Inc, a regenerative medicine company spun off the lab.
Several research projects focusing on liver tissue engineering are available, from the more fundamental encompassing the study of liver physiology and development and the pathophysiology of various liver diseases, to the more translational aiming at the identification and validation of new treatments for severe liver conditions affecting children and adults. Details will be discussed with applicants. The choice of a project will depend on the student skills, scientific interests, previous experience and education.
The students will join a young, international and multicultural team of passionate researchers that are devoted to develop new treatments and advance the field of regenerative medicine. The lab is located at the new CHU- Sainte-Justine Research Center (https://research.chusj.org/en/Home). The hospital is affiliated to the University of Montreal and provides state of the art equipment and a vibrant scientific environment. University of Montreal is one of the leading universities in Canada (https://www.umontreal.ca/). Interaction with the pharmaceutic industry for the translation of developed technology constitutes a significant part of the activity of the laboratory, and provides future opportunities for students after their diploma. Dr. Paganelli collaborates with renowned research groups in Canada, the U.S.A., Europe and Asia. International experiences and exchanges, if required by the student, are therefore a possibility.
We are looking for highly motivated young scientists willing to fully commit to an exciting field of science. The hired student is expected to have a specific interest in regenerative medicine, attention to detail and precision, and to be a good team player. Master degree (for PhD students) or PhD (for postdocs) in biology, medical sciences or other relevant field is required. Experience in Hepatology, cellular and molecular biology and the ability of working with animal models is an asset. To obtain the position is mandatory to have an excellent academic record, since the students will be required to apply for scholarships at the main funding agencies in Canada (FRQS, CHIR among others). Fluency in English is necessary.
Applications for postgraduate positions are accepted at the University of Montreal by September 1st and February 1st, but dates will be defined according to the program for which the student is eligible. International students also need to consider the time needed for visa application. Interested applicants are invited to start the process as soon as possible.
Submit your application:
Interested candidates should send the following documents to Dr Paganelli by email at email@example.com
- Curriculum vitae
- Transcript of grades (for MSc and PhD positions)
- Letter of motivation
- References (contact information of 2 persons, name, email and phone number)
While all candidatures will be taken in consideration, only selected students will be contacted for an interview.