Massimiliano Paganelli did his medical studies at the Sapienza University of Rome . He started caring for children with liver diseases in 2005 during his first fellowship in pediatric hepatology at the University of Naples “Federico II”. During his training in pediatrics at the Sapienza University, Dr Paganelli cultivated such an interest in gastrointestinal and liver diseases of children with an intense clinical and research activity in one of the leading specialized department in Europe. He then moved to Brussels for 18 months of subspecialty training in hepatology and liver transplantation at Cliniques Saint-Luc in Brussels (a pioneer center for pediatric liver transplantation). In Brussels, Dr Paganelli started focusing on liver cell transplantation and cell therapy for liver diseases. He did a PhD in pediatric hepatology and cell therapy at the Université catholique de Louvain, working on in vitro differentiation of stem cells to hepatocytes, in vitro disease modeling with stem cells-derived hepatocytes, and cell therapy for inborn errors of liver metabolism. His researches led to several prizes, presentations at international meetings and scientific publications. Subsequently Dr Paganelli refined his clinical training with a fellowship in pediatric gastroenterology and nutrition at CHU Sainte-Justine, where he was recruited to continue his clinical activity as pediatric gastroenterologist/hepatologist (with a special focus on liver transplantation) and carry on his research on the use of stem cells for the treatment of liver diseases. Recently, Dr Paganelli was the first non-American to be awarded with the prestigious “Research Scholar in Liver Disease Award” from Gilead Sciences.